Modena BD, et al. Gene Expression Correlated to Severe Asthma Characteristics Reveals Heterogeneous Mechanisms of Severe Disease. Am J Respir Crit Care Med. 2016 Dec 16. doi: 10.1164/rccm.201607-1407OC. PMID: 27984699. 

Riley CM, et al. Clinical Implications of Having Reduced Mid Forced Expiratory Flow Rates (FEF25-75),  Independently of FEV1, in Adult Patients with Asthma. PLoS One. 2015 Dec 30;10(12):e0145476. doi: 10.1371/journal.pone.0145476. PMID: 26717486; PMCID:PMC4696666. 

Zein JG, et al. Asthma Is More Severe in Older Adults. PLoS One. 2015 Jul 22;10(7):e0133490. doi: 10.1371/journal.pone.0133490. PMID: 26200463; PMCID: PMC4511639. 

Marozkina NV, et al. Phenotype of asthmatics with increased airway S-nitrosoglutathione reductase activity. Eur Respir J. 2015 Jan;45(1):87-97. doi:10.1183/09031936.00042414. Erratum in: Eur Respir J. 2015 Jun;45(6):1763. PMID: 25359343; PMCID: PMC4283933. 

Wu W, et al. Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data. J Allergy Clin Immunol. 2014 May;133(5):1280-8. doi: 10.1016/j.jaci.2013.11.042.PMID: 24589344; PMCID: PMC4038417. 

Wysocki K, et al. Characterization of factors associated with systemic corticosteroid use in severe asthma: data from the Severe Asthma Research Program. J Allergy Clin Immunol. 2014 Mar;133(3):915-8. doi: 10.1016/j.jaci.2013.10.031. PMID: 24332222; PMCID: PMC4086875. 

Johansson MW, et al. Markers of vascular perturbation correlate with airway structural change in asthma. Am J Respir Crit Care Med. 2013 Jul 15;188(2):167-78. doi: 10.1164/rccm.201301-0185OC. PMID: 23855693; PMCID: PMC3778758. 

Hastie AT, et al. Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects. J Allergy ClinImmunol. 2013 Jul;132(1):72-80. doi: 10.1016/j.jaci.2013.03.044. PMID: 23706399; PMCID: PMC3704048. 

Sah PK, et al. Poor asthma control in obese children may be overestimated because of enhanced perception of dyspnea. J Allergy Clin Immunol Pract. 2013 Jan;1(1):39-45. PMID: 23646295; PMCID: PMC3643518. 

Rao CK, et al. Characteristics of perimenstrual asthma and its relation to asthma severity and control: data from the Severe Asthma Research Program. Chest. 2013 Apr;143(4):984-92. doi: 10.1378/chest.12-0973. PMID: 23632943; PMCID: PMC3747720. 

Holguin F, et al. An association between L-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype. Am J Respir Crit Care Med. 2013 Jan 15;187(2):153-9. doi: 10.1164/rccm.201207-1270OC. PMID: 23204252; PMCID: PMC3570651. 

Coleman JM, et al. Epithelial eotaxin-2 and eotaxin-3 expression: relation to asthma severity, luminal eosinophilia and age at onset. Thorax. 2012 Dec;67(12):1061-6. doi: 10.1136/thoraxjnl-2012-201634. PMID: 23015684; PMCID: PMC3652589. 

Li X, et al. Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases. J Allergy Clin Immunol. 2012 Oct;130(4):861-8.e7. doi: 10.1016/j.jaci.2012.04.041. PMID: 22694930; PMCID: PMC3579216. 

Luyster FS, et al. Sleep quality and asthma control and quality of life in non-severe and severe asthma. Sleep Breath. 2012 Dec;16(4):1129-37. doi: 10.1007/s11325-011-0616-8. PMID: 22102290; PMCID: PMC3617495. 

Castro M, et al. Lung imaging  in asthmatic patients: the picture is clearer. J Allergy Clin Immunol. 2011 Sep;128(3):467-78. doi: 10.1016/j.jaci.2011.04.051. Review. PMID:21636118; PMCID: PMC3187916. 

Holguin F, et al. Obesity and asthma: an association modified by age of asthma onset. J Allergy Clin Immunol. 2011 Jun;127(6):1486-93.e2. doi:10.1016/j.jaci.2011.03.036. PMID: 21624618; PMCID:PMC3128802. 

Comhair SA, et al. Detrimental effects of environmental tobacco smoke in relation to asthma severity. PLoS One. 2011 May 4;6(5):e18574. doi: 10.1371/journal.pone.0018574. PMID: 21572527; PMCID: PMC3087715. 

Moore WC, et al. Safety of investigative bronchoscopy in the Severe Asthma Research Program. J Allergy Clin Immunol. 2011 Aug;128(2):328-336.e3. doi: 10.1016/j.jaci.2011.02.042. PMID: 21496892; PMCID: PMC3149754. 

Sorkness RL, et al. Sex dependence of airflow limitation and air trapping in children with severe asthma. J Allergy Clin Immunol. 2011 Apr;127(4):1073-4. doi: 10.1016/j.jaci.2010.12.1079. PMID: 21310476; PMCID:PMC3078583. 

Fitzpatrick AM, Teague WG. Progressive airflow limitation is a feature of children with severe asthma. J Allergy Clin Immunol.2011 Jan;127(1):282-4. doi: 10.1016/j.jaci.2010.10.036. PMID: 21211661; PMCID: PMC3034305. 

Fitzpatrick AM, et al. Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program. J Allergy Clin Immunol. 2011 Feb;127(2):382-389.e1-13. doi:10.1016/j.jaci.2010.11.015. PMID: 21195471; PMCID: PMC3060668. 

Gamble C, et al. Racial differences in biologic predictors of severe asthma: Data from the Severe Asthma Research Program. J Allergy Clin Immunol. 2010 Dec;126(6):1149-56.e1. doi:10.1016/j.jaci.2010.08.049. PMID: 21051082; PMCID: PMC3021754. 

Fitzpatrick AM, et al. Glutathione oxidation is associated with airway macrophage functional impairment in children with severe asthma. Pediatr Res.2011 Feb;69(2):154-9. doi: 10.1203/PDR.0b013e3182026370. PMID: 20975618; PMCID: PMC3066054. 

Balzar S, et al. Mast cell phenotype, location, and activation in severe asthma. Data from the Severe Asthma Research Program. Am J Respir Crit Care Med. 2011 Feb 1;183(3):299-309. doi: 10.1164/rccm.201002-0295OC. PMID: 20813890; PMCID: PMC3056228. 

Hastie AT, et al. Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes. J Allergy Clin Immunol. 2010 May;125(5):1028-1036.e13. doi: 10.1016/j.jaci.2010.02.008. PMID: 20398920; PMCID: PMC2878277. 

Fitzpatrick AM, et al. The molecular phenotype of severe asthma in children. J Allergy Clin Immunol. 2010 Apr;125(4):851-857.e18. doi: 10.1016/j.jaci.2010.01.048. PMID: 20371397; PMCID:PMC2851636. 

Wedes SH, et al. Noninvasive markers of airway inflammation in asthma. Clin Transl Sci. 2009 Apr;2(2):112-7. doi: 10.1111/j.1752-8062.2009.00095.x. PMID: 20234847; PMCID: PMC2838203. 

Dweik RA, et al. Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma. Am J Respir Crit Care Med. 2010 May 15;181(10):1033-41. doi: 10.1164/rccm.200905-0695OC. PMID: 20133930; PMCID: PMC2874447. 

Fitzpatrick AM, et al. Levels of nitric oxide oxidation products are increased in the epithelial lining fluid of children with persistent asthma. J Allergy Clin Immunol. 2009 Nov;124(5):990-6.e1-9. doi: 10.1016/j.jaci.2009.08.039. PMID: 19895987; PMCID: PMC2776730. 

Moore WC, et al. Identification of asthma phenotypes using clusteranalysis in the Severe Asthma Research Program. Am J Respir Crit Care Med. 2010 Feb 15;181(4):315-23. doi: 10.1164/rccm.200906-0896OC. PMID: 19892860; PMCID: PMC2822971.

 

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